Real - Time Cell Analyzer 



A compact, iPad wireless operated RTCA Analyzer for Cell-based assays.

The new iCELLigence system from ACEA Biosciences is a unique, impedance-based system for cell-based assays, allowing for label-free and real-time monitoring of cellular processes such as cell growth, proliferation, cytotoxicity, adhesion, morphological dynamics and modulation of barrier function.

The RTCA iCELLigence System is composed of three main components:
• RTCA iCELLigence Analyzer
• RTCA Control Unit (iPad)
• E-Plate L8
iCELLigence Instrument Highlights:
• iPad compatible GUI 
• Intuitive workflows 
• Wireless data acquisition



For both high-throughput screening and research laboratory environments

RTCA SystemRTCA Cardio

The RTCA Cardio Instrument is a high-resolution system for label-free-dual-mode monitoring of cardiomyocyte and cardiotoxicity testing
The RTCA HT Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors
The RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16



Single-use,used for performing cell-based assays on the RTCA System

RTCA System

E-Plate Inserts
E-Plate Inserts are single use, disposable devices used for performing cell-cell interaction assays on the RTCA DP, SP, MP, Cardio or iCELLigence Instruments.
CIM-Plate 16
CIM-Plates 16 are single use, disposable devices used for performing cell invasion and cell migration assays on the RTCA DP Instrument
E-Plate 16
E-Plates are single-use, disposable devices used for performing cell-based assays on the xCELLigence system


Dedicated software are developed to operate xCELLigence Systems for instrument setup, control and operation, flexible experiment setups, data acquisition, data display and output, and data analysis. 

RTCA iCELLigence Software
The wireless RTCA iCELLigence System is driven by powerful and dedicated software for all aspects of experimental setup and handling.
RTCA Software 1.2
The xCELLigence system RTCA instruments are driven by powerful, dedicated software

Technology - Principle

The presence of the cells on top of the electrodes will affect the local ionic environment at the electrode/solution interface, leading to an increase in the electrode impedance. The more cells are attached on the electrodes, the larger the increases in electrode impedance. In addition, the impedance depends on the quality of the cell interaction with the electrodes. For example, increased cell adhesion or spreading will lead to a larger change in electrode impedance. Thus, electrode impedance, which is displayed as cell index (CI) values, can be used to monitor cell viability, number, morphology, and adhesion degree in a number of cell-based assays.


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